SSRI for depression blocks reuptake
An SSRI (selective serotonin reuptake inhibitor) is the usual drug for unipolar depression; examples are fluoxetine, sertraline, citalopram. The marks are in the mode of action: the sending neuron releases serotonin into the synapse; the SSRI blocks its reuptake, so the serotonin already released stays there longer and keeps stimulating the receiving neuron. Key point: it does not add serotonin, it stops reabsorption. Mood lifts only after about 2-4 weeks.
Addiction: substitute, blocker, aversive
Drug treatment for addiction has three routes; name the type, the example and the mechanism. Substitute (methadone): acts on the same receptors in a controlled dose, preventing withdrawal without the high, and the dose can be tapered. Blocker (naltrexone): occupies the receptors so the substance can no longer produce its reward. Aversive (disulfiram): stops alcohol being fully broken down, so drinking brings flushing and nausea, not pleasure.
Strengths and weaknesses come in pairs
Evaluation is examinable content here — learn matched pairs. Strengths: objective trial evidence (drug vs a placebo); low demand (a daily tablet vs weekly therapy); faster and cheaper than therapy; it can make later therapy possible. Weaknesses: side effects; it treats symptoms not causes, so relapse is common once stopped; dependence; poor compliance; and it is reductionist.
Drawn from real examiner reports.
"Makes them happier" scores nothing
The recorded failure here. Scores nothing: "the tablets make Shaun happier" — it names no treatment or mechanism. Scores: name the SSRI and give its mode of action — it blocks serotonin's reuptake so more stays in the synapse. The trap: an SSRI does not add serotonin, it blocks reabsorption, so "it gives the brain more serotonin" is the wrong mechanism.
Weak answers said only that the drug would make the person happier; the best named SSRIs and their mode of action (June 2019 P1 Q11c).
Name a strength/weakness, then explain it
Short evaluation items are constant here, and identification without justification is the named failure. "A weakness is the side effects" is only a label. Explained: "the side effects arrive before the mood lifts, which means people feel worse and stop the tablets." Write the label, add "and this matters because…", then finish it.
Identification without justification on strength and weakness items (June 2024 P1 Q11b, Q15b); "explain a strength" must not be merely described (June 2023 P2 Summary; June 2024 P2 Summary).
Weakness asked, improvement given
Read the verb twice. A weakness says what is wrong with the treatment: "it does not address the cause, so relapse is likely." An improvement says what to do differently: "combine it with therapy." They are not interchangeable — an improvement given where a weakness was asked scores nothing. If it starts with "they should…", it is an improvement.
A weakness given where an improvement was asked, and the reverse (June 2019 P2 Q3c; June 2024 P1 Q5b, Q18b).
Withdrawal isn't a feature of addiction
On an addiction-treatment question, do not slide into describing the addiction itself. On a features-of-addiction item the scheme wanted impaired control and similar, and "withdrawal symptoms" was not creditworthy. Withdrawal belongs here only as the thing a substitute drug prevents — part of the treatment's mechanism, not a feature of the addiction.
On features of addiction the scheme wanted impaired control, and "withdrawal symptoms" was non-creditworthy (June 2023 P1 Q10).
Substitute vs blocker: opposite mechanisms
Opposite mechanisms — swap them and one drug becomes the other. A substitute (methadone) acts on the same receptors, preventing withdrawal. A blocker (naltrexone) occupies those receptors so the substance cannot act. For the difference, a connective ("whereas") earns the second mark; two definitions with no contrast score once.
A "describe the difference" answered as two separate definitions scores one mark; the connective earns the second (June 2019 P1 Q6; June 2022 P1 Q7, Q22).
A 2-mark describe needs two unique points
A 2-mark describe wants two different points, not one reworded. "It has side effects" said two ways is one point and scores once. Pair points from different areas — for a substitute drug: (1) it acts on the same receptors so withdrawal is prevented, and (2) the dose is controlled and tapered. Two marks; check the second adds something new.
A 2-mark describe needs two unique points, not one twice (June 2023 P2 Q22).
Not a cure, not instant, don't stop early
Three beliefs distort answers; each correction is worth AO3. "A drug cures it" — no, it relieves symptoms; it changes chemistry, not the cause, so relapse is common once it stops. "It works straight away" — no, an SSRI takes about 2-4 weeks, and side effects come first. "Stop when you feel better" — that shows it is working, not gone.
Weak answers claimed only that the drug would make the person happier (June 2019 P1 Q11c), and most scored 0-1 when asked for a weakness of a treatment (Nov 2020 P1 Q10b).
AO3 is locked until AO2 — the name isn't AO2
AO2 and AO3 are marked separately, but AO3 cannot be awarded without AO2 — an evaluation with no link to the person scores zero for both. The name, repeating the stem and copying a line are not application. Only the scenario's own detail counts.
9-mark Assess: plan it in four moves
The 9-mark Assess is AO1 3 / AO2 3 / AO3 3, and the 7-9 band is missed for lack of AO3 and balance. Plan: name the treatment and its mode of action; tie two scenario details to it; then argue both sides and conclude. Prose, not bullet points.
Match the command word
Underline the operative verb first. State/name = the term only. Describe = two unique points. Explain a strength/weakness = the point plus why it matters. Assess = both sides, then a conclusion. Answering the wrong verb loses marks on content you know.
SSRI — a selective serotonin reuptake inhibitor, the usual drug treatment for unipolar depression. Named examples: fluoxetine, sertraline, citalopram.
Synapse — the tiny gap between two neurons, which a neurotransmitter crosses to pass the signal on.
Reuptake — the reabsorption of a neurotransmitter back into the sending neuron after it has been released.
Placebo — an identical-looking tablet containing no active drug, given to a comparison group in a trial.
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